Patients were treated according to local protocols. Objective To examine the clinical phenotypes, treatment responses, and outcomes of children with relapsing MOG-Ab–associated disease.ĭesign, Setting, and Participants This study prospectively collected demographic, clinical, and radiologic data from 102 patients from 8 countries of the EU Paediatric Demyelinating Disease Consortium from January 1, 2014, through December 31, 2016. Current therapeutic strategies are largely center specific, and no treatments have been formally evaluated. Importance Myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) are consistently identified in a range of demyelinating disorders in adults and children. Shared Decision Making and Communication.Scientific Discovery and the Future of Medicine.Health Care Economics, Insurance, Payment.Clinical Implications of Basic Neuroscience.Challenges in Clinical Electrocardiography.The clinical phenotypes of all treated patients are given in the eTable in the Supplement. Patient 52 presented initially with bilateral optic neuritis, relapsed 2 years later with transverse myelitis, experienced cognitive and psychiatric problems, and died at 20 years of age of progressive encephalopathy and respiratory failure. Twenty-eight patients remained relapse free while receiving treatment 7 of 15 (46.7%) treated with mycophenolate mofetil, 10 of 20 (50.0%) treated with azathioprine, 1 of 7 (14.2%) treated with rituximab alone, 6 of 10 (60.0%) treated with intravenous immunoglobulin (IVIG), and 2 of 2 (100%) treated with rituximab and IVIG together. All patients treated with first-line injectable multiple sclerosis treatment continued to relapse. Patient relapsed while undergoing all treatments, with a total of 127 relapses during treatment reported in the cohort. Each solid marker denotes a demyelinating event, with the color in the figure key denoting respective treatment, whereas an open marker denotes initiation of therapy.
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